Anti-HDAC4(N-term) Monoclonal Antibody

品牌：Solarbio | 货号：K000010M

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000010M-50ul	Solarbio	50ul	960.00元
K000010M-100ul	Solarbio	100ul	1600.00元

英文名称	Mouse HDAC4(N-term) Monoclonal Antibody
应用2	WB IP
克隆类型2	Monoclonal Antibody
别名	HDAC4(N-term)
应用	WB,IP
稀释比例	WB1:1000
交叉反应	Human
蛋白分子量	140kDa
Gene ID	9759
保存	Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 62% Glycerol.
纯化方法	Affinity purification
亚型	IgG2a
免疫原	Purified recombinant human HDAC4 protein fragments expressed in E.coli
性状	Lyophilized or Liquid
Swiss Prot	P56524
克隆号	4A3-H7-C6
克隆类型	Monoclonal Antibody
来源	Mouse
背景资料	CytoplasmChromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.HDAC4 is a class II histone deacetylase containing 1084 amino acid residues. HDAC4 has been shown to interact with NCoR. HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.